The term "Micro-dose" was coined in 2011 by Dr James Fadiman in the release of his book The Psychedelic Explorers Guide (which we highly recommend). He Defined it as approximately 1/10th of a hallucinogenic dose, or between 100 and 250mg for Psilocybin Mushrooms. Albert Hoffman (the inventor of LSD) has also been quoted suggesting that taking a minuscule amount of a Psychedelic substance could have positive impact on mental health and physical functioning.
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The active compounds found Psilocybin mushrooms are known as Psilocybin and Psilocin. When ingested Psilocybin is rapidly dephosphorylated by the liver into Psilocin. Psilocin has a molecular structure very similar to the endogenous neurotransmitter serotonin, this allows it to bind to the 5-HT2A serotonin receptor, producing the positive effects on mood, anxiety, focus, creativity, and memory that are currently being researched.
Stimulating the 5-HT2A receptor leads to two important results:
- The production of “Brain Derived Neurotrophic Factor” (BDNF) which is “like Miracle-Gro for your brain". It stimulates growth, connections, and activity.
- The increased transmission of “Glutamate,” the neurotransmitter responsible for brain functions like cognition, learning, and memory.
Read more about the Pharmacology of Psilocybin