The term "Micro-dose" was coined in 2011 by Dr James Fadiman in the release of his book The Psychedelic Explorers Guide (which we highly recommend). He Defined it as approximately 1/10th of a hallucinogenic dose, or between 100 and 250mg for Psilocybin Mushrooms, and recommended it be taken once every 3 days. Albert Hoffman (the inventor of LSD) has also been quoted suggesting that taking a minuscule amount of a Psychedelic substance could have positive impact on mental health and physical functioning.
These two, along with many other researchers and psychonauts (Like Paul Stamets and Michael Pollan) are accredited, well respected individuals who have been exposed to the monumental amount of anecdotal evidence that Micro-dosing benefits mood, anxiety, focus, creativity and empathy. Here is a succinct informational interview from the Joe Rogan Experience podcast #1385 with Paul Stamets that epitomizes this kind of evidence, anecdotal but by no means invaluable.
While the exponentially increasing anecdotal evidence is vast, it is not grounds for a conclusive scientifically backed statement or fact. However this will not be the case for long. Multiple studies have already been conducted (albeit with small sample sizes), and many are cited below. Moreover numerous accredited universities like Harvard, Stanford, University of Toronto, and John Hopkins are in the process of conducting human clinical trials using Psilocybin to treat a variety of psychological conditions including depression, anxiety, PTSD, OCD, addiction, and eating disorders.
One Study at the University of Bergen found that the respondents reported mostly positive effects, including improved mood, cognition, and creativity. Furthermore, these effects “often served to counteract symptoms especially from conditions of anxiety and depression.”
In Conclusion the field of research around psychedelics is still in its infancy. Results from preliminary studies have shown promise for the safety and efficacy of microdosing psychedelics and future research is primed by the credentials of many institutions who have chosen to involve themselves in pioneering this field. The coming years will prove enlightening for citizens and scientists alike who want to know more about the science behind microdosing.